Project Overview

The ‘PROFILE’ Innovative Trainning Network (European Industrial Doctoral programme) aims at stratifying acquired thrombotic thrombocytopenic purpura (TTP) patients by understanding disease pathology, using new types of biomarkers and predicting their risk for relapse.

The outcome of this project will be crucial for treatment adjustment in these patients and development of personalized medicine in the future. To stratify acquired TTP patients (or any other patients with an autoimmune disorder), a unique research approach and specialized translational training programme is needed.

Objectives

The following objectives will be executed to achieve this innovative European Industrial Doctoral programme:

Objective 1:
To decipher the pathophysiology of acquired TTP at the molecular level

Objective 2:
To establish immunoprofiling as a new type of biomarker for the stratification of patients

Objective 3:
To link biomarkers with disease prognosis

Objective 4:
To develop novel treatment strategies and test them in preclinical animal models

Objective 5:
To provide a unique translational training programme with important links to clinic and industry

Objective 6:
Outreach, dissemination and exploitation

Funded by the Horizon 2020
Framework Programme of the
European Union