Blood publications November 2016

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Volume 128, issue 21 of Blood Journal contains the contribution of Prof Dr Jan Voorberg who guided the design and supervised the experiments of the research article entitled “Identification of glycans on plasma-derived ADAMTS13”. Additionally, Prof Dr Karen Vanhoorelbeke, with her comment “Glycans of plasma ADAMTS13” provides a critical review of this research.

The first manuscript shows the glycan composition on plasma ADAMTS13 and the second one offers an overview about previous investigations done in this filed, highlighting the importance of this kind of studies.

You can find both publications in this link

ESRs located in KULeuven attended the BSTH 2016

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The students had the chance to meet researchers from universities and hospital centers from over Belgium and get to know the main research areas from the different scientific approaches related to thrombopathies.

Prof Dr Karen Vanhoorelbeke, coordinator of PROFILE, participated as moderator of the session regarding the state of art of “Flow and thrombosis cardiology”.

The programme covered cardiology and haemostasis fields, with the state-of-art lectures focused on platelets and thrombosis and flow and thrombosis in cardiology. Additionally, experts from different countries provided satellite symposia related to the efficacy of treatment and management of bleeding disorders.

ESR participated in the NSBM fall meeting

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The Netherlands Society on Biomolecular Modelling fall meeting, was held on November 16th 2016, at the University Library De Uithof, CS Utrecht, The Netherlands. The event brought together people working on three dimensional structures of biomolecules and biomolecular simulations.

Boğaç Erçığ participated with his poster based on “Structural bioinformatics investigation of the structure of human ADAMTS13”, to better understand domain interactions and mechanisms in order to develop novel therapeutics and diagnostic tools.

Boğaç Erçığ at the NSBM fall meeting in the Poster session

Boğaç Erçığ at the NSBM fall meeting in the Poster session

Early Stage Researcher receives training

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As part of her doctoral training, Early Stage Researcher, Johana Hrdinova, attended a course on virtual screening and ADMET in-silico at University Paris Diderot from November 15 to 24, 2016.

The course was a practical training on the use of structural bioinformatics and chemoinformatics in the area of life and health sciences.

AP-HP partners publication: “Assessment of endothelial damage and cardiac injury in a mouse model mimicking thrombotic thrombocytopenic purpura”

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Prof Dr MD Paul Coppo and Prof Dr MD Agnes Veyradier participated in the results interpretation of the study entitled: “Assessment of endothelial damage and cardiac injury in a mouse model mimicking thrombotic thrombocytopenic purpura”.

One of the symptoms developed by TTP patients is multiple organ failure. One of the affected organ is the heart, however heart failure in TTP patients have been poorly studied. This motivated the authors of the article to investigate this event with the objective to assess the changes in endothelial function and the induced cardiac damage by injecting rVWF in an ADAMTS13 knock out mouse to induce TTP like symptoms.

The study shows that in the murine TTP model used there is a strong mesenteric and coronary endothelial dysfunction due to the occurrence of a pro-oxidant state, and pro-adhesive and pro-inflammatory phenotypes of endothelial cells from the cardiac microcirculation. These finding suggest that alterations produced by TTP microthrombi amplify the pathophysiology of the disease.

The article was published in the Journal of Thrombosis and Haemostasis, and you can find it here.